The Henchmen are instruments of your evil will, they take direct orders from you, but they are above performing menial tasks like building rooms or moving body bags. You will start the game with one henchman, but more will seek to join your evil empire as your notoriety grows through special Acts of Infamy, where you find and recruit new henchmen from a variety of locations by dispatching agents to war zones in search of talent, scouring universities for insane scientists, or launching prison breaks to free captured henchmen.
They are the most powerful weapons in the player's arsenal, who can deal and withstand more damage than your minions. In addition to their standard attacks, all Henchmen have three special abilities. One of them is the "Gather Minions" skill, which will rally nearby minions and have them follow that henchman for a short period of time. The other two abilities are unlocked by the accumulation of experience points, which is gained by killing agents or having them participate in successful Acts of Infamy.
All henchman have three lives. They cannot be killed normally. When normal agents take out your henchman, they will be rendered unconscious and a Social Minion will attempt to carry them to the Barracks, where they will wake up. A henchman loses a life when receiving 80% of damage or more from a Super Agent and knockout in a single fight. There is no legitimate way to restore their lost life. If all three lives are lost, a henchman is gone permanently for the rest of the game.
- Colonel Blackheart 
- Dr. Neurocide
- The Matron
- Red Ivan 
- The Butcher
- The Great Mesmero
Extra Information Edit
- ↑ 1.0 1.1 1.2 Colonel Blackheart is available through GOG
- ↑ 2.0 2.1 2.2 2.3 Red Ivan will carry a bazooka and potentially blow up your base and kill your minions
|Military||Guard / Mercenary / Marksman / Martial Artist|
|Science||Technician / Scientist / Quantum Physicist / Biochemist|
|Social||Valet / Spindoctor / Diplomat / Playboy|
|Other||Construction Worker / Personal Bodyguards / Freaks|
|Henchmen||Colonel Blackheart / Dr. Neurocide / Eli Barracuda / Jubei / Lord Kane / Moko / The Butcher / The Great Mesmero / The Matron / Montezuma / Red Ivan|